[HTML][HTML] The acrosomal protein Dickkopf-like 1 (DKKL1) facilitates sperm penetration of the zona pellucida

MJ Kohn, J Sztein, R Yagi, ML DePamphilis… - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To determine the role of Dkkl1 in mouse development, viability, and fertility.
DESIGN: Prospective experimental study. SETTING: Government research institution.
ANIMAL (S): Mice of C57BL/6, B6D2F1/J, and 129X1/SvJ strains, as well as transgenic mice
of mixed C57BL/6 and 129X1/SvJ strains were used for the studies. INTERVENTION (S):
Expression of the Dkkl1 gene was characterized during early mouse development, and the
effects of Dkkl1 ablation on reproduction and fertility were characterized in vitro and in vivo …