[HTML][HTML] Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization
Fertilin, a heterodimeric protein complex composed of α (ADAM1) and β (ADAM2) subunits
on the sperm surface, is believed to mediate adhesion and fusion between the sperm and
egg plasma membranes. Here we have shown that mutant male mice lacking ADAM1b are
fertile and that the loss of ADAM1b results in no significant defect in sperm functions such as
migration from the uterus into oviduct, binding to egg zona pellucida, and fusion with zona
pellucida-free eggs. ADAM1b-deficient epididymal sperm showed a severe reduction of …
on the sperm surface, is believed to mediate adhesion and fusion between the sperm and
egg plasma membranes. Here we have shown that mutant male mice lacking ADAM1b are
fertile and that the loss of ADAM1b results in no significant defect in sperm functions such as
migration from the uterus into oviduct, binding to egg zona pellucida, and fusion with zona
pellucida-free eggs. ADAM1b-deficient epididymal sperm showed a severe reduction of …