[HTML][HTML] PGAP1 knock-out mice show otocephaly and male infertility
A palmitate linked to the inositol in glycosylphosphatidylinositol (GPI) is removed in the
endoplasmic reticulum immediately after the conjugation of GPI with proteins in most cells.
Previously, we identified PGAP1 (post GPI attachment to proteins 1) as a GPI
inositoldeacylase that removes the palmitate from inositol. A defect in PGAP1 caused a
delay in the transport of GPI-anchored proteins (GPI-APs) from the endoplasmic reticulum to
the cell surface in Chinese hamster ovary cells, although the cell-surface expression of GPI …
endoplasmic reticulum immediately after the conjugation of GPI with proteins in most cells.
Previously, we identified PGAP1 (post GPI attachment to proteins 1) as a GPI
inositoldeacylase that removes the palmitate from inositol. A defect in PGAP1 caused a
delay in the transport of GPI-anchored proteins (GPI-APs) from the endoplasmic reticulum to
the cell surface in Chinese hamster ovary cells, although the cell-surface expression of GPI …