[HTML][HTML] Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from Smad
Y Park, ET Maizels, ZJ Feiger, H Alam… - Journal of Biological …, 2005 - ASBMB
Ovarian follicles undergo exponential growth in response to follicle-stimulating hormone
(FSH), largely as a result of the proliferation of granulosa cells (GCs). In vitro under serum-
free conditions, rat GCs differentiate in response to FSH but do not proliferate unless activin
is also present. In the presence of FSH plus activin, GCs exhibit enhanced expression of
cyclin D2 as well as inhibin-α, aromatase, steroidogenic factor-1 (SF-1), cholesterol side
chain (SCC), and epiregulin. In this report we sought to identify the signaling pathways by …
(FSH), largely as a result of the proliferation of granulosa cells (GCs). In vitro under serum-
free conditions, rat GCs differentiate in response to FSH but do not proliferate unless activin
is also present. In the presence of FSH plus activin, GCs exhibit enhanced expression of
cyclin D2 as well as inhibin-α, aromatase, steroidogenic factor-1 (SF-1), cholesterol side
chain (SCC), and epiregulin. In this report we sought to identify the signaling pathways by …