Induction of blastocyst implantation in mice by cyclic AMP

PV Holmes, S Bergström - Reproduction, 1975 - rep.bioscientifica.com
PV Holmes, S Bergström
Reproduction, 1975rep.bioscientifica.com
Oestrogen administration to female mice withdelayed'implantation induces changes in the
uterus and blastocysts followed by implantation and normal gestation. The second
messenger for oestrogen, adenosine 3′: 5′-cyclic monophosphate (cAMP), was instilled
into the uterine lumen of females withdelayed implanting'blastocysts to determine whether it
also is able to induce implantation. Implantation of the blastocysts was induced by cAMP but
the pregnancies were not maintained to term. These results are discussed with respect to …
Summary
Oestrogen administration to female mice with `delayed' implantation induces changes in the uterus and blastocysts followed by implantation and normal gestation. The second messenger for oestrogen, adenosine 3′:5′-cyclic monophosphate (cAMP), was instilled into the uterine lumen of females with `delayed implanting' blastocysts to determine whether it also is able to induce implantation. Implantation of the blastocysts was induced by cAMP but the pregnancies were not maintained to term. These results are discussed with respect to the changes in blastocysts induced by cAMP and with respect to the reported contraceptive effects of cAMP in normal mice.
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