Mouse models of male infertility
HJ Cooke, PTK Saunders - Nature reviews genetics, 2002 - nature.com
HJ Cooke, PTK Saunders
Nature reviews genetics, 2002•nature.comSpermatogenesis is a complex process that involves stem-cell renewal, genome
reorganization and genome repackaging, and that culminates in the production of motile
gametes. Problems at all stages of spermatogenesis contribute to human infertility, but few of
them can be modelled in vitro or in cell culture. Targeted mutagenesis in the mouse provides
a powerful method to analyse these steps and has provided new insights into the origins of
male infertility.
reorganization and genome repackaging, and that culminates in the production of motile
gametes. Problems at all stages of spermatogenesis contribute to human infertility, but few of
them can be modelled in vitro or in cell culture. Targeted mutagenesis in the mouse provides
a powerful method to analyse these steps and has provided new insights into the origins of
male infertility.
Abstract
Spermatogenesis is a complex process that involves stem-cell renewal, genome reorganization and genome repackaging, and that culminates in the production of motile gametes. Problems at all stages of spermatogenesis contribute to human infertility, but few of them can be modelled in vitro or in cell culture. Targeted mutagenesis in the mouse provides a powerful method to analyse these steps and has provided new insights into the origins of male infertility.
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