[HTML][HTML] Oxidative modification of peroxiredoxin is associated with drug-induced apoptotic signaling in experimental models of Parkinson disease
YM Lee, SH Park, DI Shin, JY Hwang, BK Park… - Journal of Biological …, 2008 - ASBMB
The aim of this study was to investigate changes in protein profiles during the early phase of
dopaminergic neuronal death using two-dimensional gel electrophoresis in conjunction with
mass spectrometry. Several protein spots were identified whose expression was significantly
altered following treatment of MN9D dopaminergic neuronal cells with 6-hydroxydopamine
(6-OHDA). In particular, we detected oxidative modification of thioredoxin-dependent
peroxidases (peroxiredoxins; PRX) in treated MN9D cells. Oxidative modification of PRX …
dopaminergic neuronal death using two-dimensional gel electrophoresis in conjunction with
mass spectrometry. Several protein spots were identified whose expression was significantly
altered following treatment of MN9D dopaminergic neuronal cells with 6-hydroxydopamine
(6-OHDA). In particular, we detected oxidative modification of thioredoxin-dependent
peroxidases (peroxiredoxins; PRX) in treated MN9D cells. Oxidative modification of PRX …