Lysosomal cysteine proteases regulate antigen presentation
K Honey, AY Rudensky - Nature Reviews Immunology, 2003 - nature.com
K Honey, AY Rudensky
Nature Reviews Immunology, 2003•nature.comAntigen presentation by both classical MHC class II molecules and the non-classical MHC
class I-like molecule CD1D requires their entry into the endosomal/lysosomal compartment.
Lysosomal cysteine proteases constitute an important subset of the enzymes that are
present in this compartment and, here, we discuss the role of these proteases in regulating
antigen presentation by both MHC class II and CD1D molecules.
class I-like molecule CD1D requires their entry into the endosomal/lysosomal compartment.
Lysosomal cysteine proteases constitute an important subset of the enzymes that are
present in this compartment and, here, we discuss the role of these proteases in regulating
antigen presentation by both MHC class II and CD1D molecules.
Abstract
Antigen presentation by both classical MHC class II molecules and the non-classical MHC class I-like molecule CD1D requires their entry into the endosomal/lysosomal compartment. Lysosomal cysteine proteases constitute an important subset of the enzymes that are present in this compartment and, here, we discuss the role of these proteases in regulating antigen presentation by both MHC class II and CD1D molecules.
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