Treatment of adult brain tumors, in particular glioblastoma, remains a significant clinical
challenge, despite modest advances in surgical technique, radiation, and
chemotherapeutics. The formation of abnormal, dysfunctional tumor vasculature and glioma
cell invasion along white matter tracts are believed to be major components of the inability to
treat these tumors effectively. Recent insight into the fundamental processes governing
glioma angiogenesis and invasion provide a renewed hope for development of novel …