Abstract DESPITE SIGNIFICANT IMPROVEMENTS, current therapies have yet to cure
infiltrative gliomas. Glioma progression is strongly dependent on the development of a new
vascular network that occurs primarily by angiogenesis. Hypoxia and genetic anomalies
within a glioma trigger the angiogenic switch, thus upregulating angiogenic factors and
downregulating antiangiogenic factors. The main factors indicative of angiogenesis are now
well known, and more recently, differences based on grade and subtype have been …