Plasmodium Sporozoite Passage across the Sinusoidal Cell Layer
U Frevert, I Usynin, K Baer, C Klotz - Molecular Mechanisms of Parasite …, 2008 - Springer
U Frevert, I Usynin, K Baer, C Klotz
Molecular Mechanisms of Parasite Invasion: Subcellular Biochemistry, 2008•SpringerMalaria sporozoites must cross at least two cell barriers to reach their initial site of replication
in the mammalian host. After transmission into the skin by an infected mosquito, they migrate
towards small dermal capillaries, traverse the vascular endothelial layer, 1, 2 and rapidly
home to the liver. To infect hepatocytes, the parasites must cross the sinusoidal cell layer,
composed of specialized highly fenestrated sinusoidal endothelia and Kupffer cells, the
resident macrophages of the liver (Fig. 1). The exact route Plasmodium sporozoites take to …
in the mammalian host. After transmission into the skin by an infected mosquito, they migrate
towards small dermal capillaries, traverse the vascular endothelial layer, 1, 2 and rapidly
home to the liver. To infect hepatocytes, the parasites must cross the sinusoidal cell layer,
composed of specialized highly fenestrated sinusoidal endothelia and Kupffer cells, the
resident macrophages of the liver (Fig. 1). The exact route Plasmodium sporozoites take to …
Abstract
Malaria sporozoites must cross at least two cell barriers to reach their initial site of replication in the mammalian host. After transmission into the skin by an infected mosquito, they migrate towards small dermal capillaries, traverse the vascular endothelial layer,1,2 and rapidly home to the liver. To infect hepatocytes, the parasites must cross the sinusoidal cell layer, composed of specialized highly fenestrated sinusoidal endothelia and Kupffer cells, the resident macrophages of the liver (Fig. 1). The exact route Plasmodium sporozoites take to hepatocytes has been subject of controversial discussions for many years. Recent cell biological, microscopic, and genetic approaches have considerably enhanced our understanding of the initial events leading to the establishment of a malaria infection in the liver (for recent reviews see refs. 3–8).
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