[HTML][HTML] Oncogenic RET Receptors Display Different Autophosphorylation Sites and Substrate Binding Specificities (∗)
The c-ret proto-oncogene encodes a receptor tyrosine kinase which plays an important role
in neural crest as well as kidney development. Genetic studies have demonstrated that germ
line mutations in the ret oncogene are the direct cause of multiple endocrine neoplasia
(MEN) 2A and 2B, familial medullary thyroid carcinoma (FMTC), and Hirschsprung's
disease. However, despite the large body of genetic and biological evidence suggesting the
importance of RET in development and neoplastic processes, the signal transduction …
in neural crest as well as kidney development. Genetic studies have demonstrated that germ
line mutations in the ret oncogene are the direct cause of multiple endocrine neoplasia
(MEN) 2A and 2B, familial medullary thyroid carcinoma (FMTC), and Hirschsprung's
disease. However, despite the large body of genetic and biological evidence suggesting the
importance of RET in development and neoplastic processes, the signal transduction …