[HTML][HTML] KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations
L Agell, S Hernández, S De Muga, JA Lorente… - Modern Pathology, 2008 - Elsevier
Krüppel-like factor 6 (KLF6) has been reported to act as a tumor suppressor gene involved
in the regulation of the cell cycle by activating p21 in a p53-independent manner. Many
studies suggest that KLF6 is inactivated by allelic loss and somatic mutation. However, there
is a high variability in the reported frequency of mutations (from 1 to 55%). TP53 also
regulates the cell cycle through the activation of p21. In prostate cancer, the reported
frequency of TP53 mutations ranges from 3 to 42%. In all these reports, there is a …
in the regulation of the cell cycle by activating p21 in a p53-independent manner. Many
studies suggest that KLF6 is inactivated by allelic loss and somatic mutation. However, there
is a high variability in the reported frequency of mutations (from 1 to 55%). TP53 also
regulates the cell cycle through the activation of p21. In prostate cancer, the reported
frequency of TP53 mutations ranges from 3 to 42%. In all these reports, there is a …