[HTML][HTML] AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival
Y Li, D Dowbenko, LA Lasky - Journal of Biological Chemistry, 2002 - ASBMB
p21 Cip1/WAF1 (p21), a p53-inducible protein, is a critical regulator of cell cycle and cell
survival. p21 binds to and inhibits both the DNA synthesis regulator proliferating cell nuclear
antigen and cyclin A/E-CDK2 complexes. Recently, p21 has also been shown to be a
positive regulator of cell cycle progression as p21 is necessary for the assembly and
activation of cyclin D1-CDK4/6 complexes. Furthermore, elevated p21 protein levels have
been observed in various aggressive tumors as well as linked to chemoresistance. Here we …
survival. p21 binds to and inhibits both the DNA synthesis regulator proliferating cell nuclear
antigen and cyclin A/E-CDK2 complexes. Recently, p21 has also been shown to be a
positive regulator of cell cycle progression as p21 is necessary for the assembly and
activation of cyclin D1-CDK4/6 complexes. Furthermore, elevated p21 protein levels have
been observed in various aggressive tumors as well as linked to chemoresistance. Here we …