[HTML][HTML] Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney
M Zeisberg, AA Shah, R Kalluri - Journal of Biological Chemistry, 2005 - ASBMB
In the kidney, a unique plasticity exists between epithelial and mesenchymal cells. During
kidney development, the metanephric mesenchyme contributes to emerging epithelium of
the nephron via mesenchymal to epithelial transition (MET). In the injured adult kidney, renal
epithelia contribute to the generation of fibroblasts via epithelial-mesenchymal transition,
facilitating renal fibrosis. Recombinant human bone morphogenic protein (BMP)-7, a
morphogen that is essential for the conversion of epithelia from condensing mesenchyme …
kidney development, the metanephric mesenchyme contributes to emerging epithelium of
the nephron via mesenchymal to epithelial transition (MET). In the injured adult kidney, renal
epithelia contribute to the generation of fibroblasts via epithelial-mesenchymal transition,
facilitating renal fibrosis. Recombinant human bone morphogenic protein (BMP)-7, a
morphogen that is essential for the conversion of epithelia from condensing mesenchyme …