Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function
J Morrissey, K Hruska, G Guo, S Wang… - Journal of the …, 2002 - journals.lww.com
A prevention protocol has demonstrated that bone morphogenetic protein-7 (BMP-7) blunted
the development of fibrosis in a rat model of unilateral ureteral obstruction. This prevention
protocol also preserved, to an extent, renal function. The prevention protocol was extended
and a treatment protocol used to examine if BMP-7 was beneficial at limiting fibrosis of the
kidney when the BMP-7 was administered during the progression of fibrotic disease.
Animals were distributed into four groups. Group 1 received vehicle, group 2 received …
the development of fibrosis in a rat model of unilateral ureteral obstruction. This prevention
protocol also preserved, to an extent, renal function. The prevention protocol was extended
and a treatment protocol used to examine if BMP-7 was beneficial at limiting fibrosis of the
kidney when the BMP-7 was administered during the progression of fibrotic disease.
Animals were distributed into four groups. Group 1 received vehicle, group 2 received …