Evidence that IL-13Rα2 chain in human glioma cells is responsible for the antitumor activity mediated by receptor-directed cytotoxin therapy
K Kawakami, M Kioi, Q Liu, M Kawakami… - Journal of …, 2005 - journals.lww.com
Abstract The interleukin-13 receptor α2 (IL-13Rα2) chain is a primary IL-13 binding and
internalization component of the IL-13R system. Previous studies have shown that human
brain tumors, including glioblastoma multiforme (GBM), overexpress IL-13Rα2 chain, while
normal brain cells do not express this protein or express very low levels of it. To target IL-
13R on brain tumor cells, the authors have developed an IL-13R-directed cytotoxin termed
IL13-PE38QQR to induce specific cancer cell killing. To investigate the role of IL-13Rα2 …
internalization component of the IL-13R system. Previous studies have shown that human
brain tumors, including glioblastoma multiforme (GBM), overexpress IL-13Rα2 chain, while
normal brain cells do not express this protein or express very low levels of it. To target IL-
13R on brain tumor cells, the authors have developed an IL-13R-directed cytotoxin termed
IL13-PE38QQR to induce specific cancer cell killing. To investigate the role of IL-13Rα2 …