Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients …
L Souhami, W Seiferheld, D Brachman… - International Journal of …, 2004 - Elsevier
PURPOSE: Conventional treatment of glioblastoma multiforme (GBM) cures less than 5% of
patients. We investigated the effect of stereotactic radiosurgery (SRS) added to conventional
external beam radiation therapy (EBRT) with carmustine (BCNU) on the survival of patients
with GBM. METHODS AND MATERIALS: A total of 203 patients with supratentorial GBM
(tumor≤ 40 mm) were randomly assigned either to postoperative SRS followed by EBRT
(60 Gy) plus BCNU (80 mg/m2 Days 1–3 every 8 weeks for six cycles) or to EBRT with …
patients. We investigated the effect of stereotactic radiosurgery (SRS) added to conventional
external beam radiation therapy (EBRT) with carmustine (BCNU) on the survival of patients
with GBM. METHODS AND MATERIALS: A total of 203 patients with supratentorial GBM
(tumor≤ 40 mm) were randomly assigned either to postoperative SRS followed by EBRT
(60 Gy) plus BCNU (80 mg/m2 Days 1–3 every 8 weeks for six cycles) or to EBRT with …