Patterns of viremia and antibody observed in rhesus monkeys inoculated with chikungunya and other serologically related group A arboviruses.
LN Binn, VR Harrison, R Randall - 1967 - cabidigitallibrary.org
LN Binn, VR Harrison, R Randall
1967•cabidigitallibrary.orgRhesus monkeys were inoculated with the A group arboviruses, chikungunya (Asian and
African strains), Mayaro and o'nyong-nyong. The first two viruses gave rise to viraemia of
relatively high level and half the monkeys had fever; neutralizing, haemag-glutinin-inhibiting
and complement-fixing antibodies developed. O'nyong-nyong virus did not cause viraemia,
nor was there a significant antibody rise. Monkeys infected with either chikungunya or
Mayaro failed to show viraemia When challenged later with the other virus; this was …
African strains), Mayaro and o'nyong-nyong. The first two viruses gave rise to viraemia of
relatively high level and half the monkeys had fever; neutralizing, haemag-glutinin-inhibiting
and complement-fixing antibodies developed. O'nyong-nyong virus did not cause viraemia,
nor was there a significant antibody rise. Monkeys infected with either chikungunya or
Mayaro failed to show viraemia When challenged later with the other virus; this was …
Abstract
Rhesus monkeys were inoculated with the A group arboviruses, chikungunya (Asian and African strains), Mayaro and o'nyong-nyong. The first two viruses gave rise to viraemia of relatively high level and half the monkeys had fever; neutralizing, haemag-glutinin-inhibiting and complement-fixing antibodies developed. O'nyong-nyong virus did not cause viraemia, nor was there a significant antibody rise. Monkeys infected with either chikungunya or Mayaro failed to show viraemia When challenged later with the other virus; this was expected since the two viruses cross-react in neutralization tests. Monkeys could play a role in the ecology of chikungunya in Asia. C. H. Andrewes.
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