[HTML][HTML] The long and short isoforms of Ret function as independent signaling complexes
BA Tsui-Pierchala, RC Ahrens, RJ Crowder… - Journal of Biological …, 2002 - ASBMB
Ret, the receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family
ligands (GFLs), is alternatively spliced to yield at least two isoforms, Ret9 and Ret51, which
differ only in their C termini. To identify tyrosines in Ret that are autophosphorylation sites in
neurons, we generated antibodies specific to phosphorylated Y905Ret, Y1015Ret,
Y1062Ret, and Y1096Ret, all of which are autophosphorylated in cell lines. All four of these
tyrosines in Ret became phosphorylated rapidly upon activation by GFLs in sympathetic …
ligands (GFLs), is alternatively spliced to yield at least two isoforms, Ret9 and Ret51, which
differ only in their C termini. To identify tyrosines in Ret that are autophosphorylation sites in
neurons, we generated antibodies specific to phosphorylated Y905Ret, Y1015Ret,
Y1062Ret, and Y1096Ret, all of which are autophosphorylated in cell lines. All four of these
tyrosines in Ret became phosphorylated rapidly upon activation by GFLs in sympathetic …