[HTML][HTML] Cytosolic degradation of T-cell receptor α chains by the proteasome
H Yu, G Kaung, S Kobayashi, RR Kopito - Journal of Biological Chemistry, 1997 - ASBMB
The T-cell antigen receptor (TCR) is an hetero-oligomeric membrane complex composed of
at least seven transmembrane polypeptide chains that has served as a model for the
assembly and degradation of integral membrane proteins in the endoplasmic reticulum
(ER). Unassembled TCRα chains fail to mature to the Golgi apparatus and are rapidly
degraded by a non-lysosomal" ER degradation" pathway that has been proposed to be
autonomous to the ER. In these studies we show that the degradation of core-glycosylated …
at least seven transmembrane polypeptide chains that has served as a model for the
assembly and degradation of integral membrane proteins in the endoplasmic reticulum
(ER). Unassembled TCRα chains fail to mature to the Golgi apparatus and are rapidly
degraded by a non-lysosomal" ER degradation" pathway that has been proposed to be
autonomous to the ER. In these studies we show that the degradation of core-glycosylated …