Suppressing cancer: the importance of being senescent
J Campisi - Science, 2005 - science.org
J Campisi
Science, 2005•science.orgCell senescence as an anticancer defense. Mutations that activate the oncogenes Ras or
BRAF or inactivate the tumor suppressor Pten produce premalignant (early-stage) lesions. If
there is additional loss of p53 or p16/pRB function, premalignant cells cannot undergo
cellular senescence and progress instead into malignant tumors.
BRAF or inactivate the tumor suppressor Pten produce premalignant (early-stage) lesions. If
there is additional loss of p53 or p16/pRB function, premalignant cells cannot undergo
cellular senescence and progress instead into malignant tumors.
Cell senescence as an anticancer defense. Mutations that activate the oncogenes Ras or BRAF or inactivate the tumor suppressor Pten produce premalignant (early-stage) lesions. If there is additional loss of p53 or p16/pRB function, premalignant cells cannot undergo cellular senescence and progress instead into malignant tumors.
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