[HTML][HTML] High‐mobility group box 1 protein promotes development of microvascular thrombosis in rats
T Ito, K Kawahara, T Nakamura, S Yamada… - Journal of Thrombosis …, 2007 - Elsevier
Background: Sepsis is a life‐threatening disorder resulting from systemic inflammatory and
coagulatory responses to infection. High‐mobility group box 1 protein (HMGB1), an
abundant intranuclear protein, was recently identified as a potent lethal mediator of sepsis.
However, the precise mechanisms by which HMGB1 exerts its lethal effects in sepsis have
yet to be confirmed. We recently reported that plasma HMGB1 levels correlated with
disseminated intravascular coagulation (DIC) score, indicating that HMGB1 might play an …
coagulatory responses to infection. High‐mobility group box 1 protein (HMGB1), an
abundant intranuclear protein, was recently identified as a potent lethal mediator of sepsis.
However, the precise mechanisms by which HMGB1 exerts its lethal effects in sepsis have
yet to be confirmed. We recently reported that plasma HMGB1 levels correlated with
disseminated intravascular coagulation (DIC) score, indicating that HMGB1 might play an …