[HTML][HTML] Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1
Toll-like receptor 4 (TLR4) and TLR2 agonists from bacterial origin require acylated
saturated fatty acids in their molecules. Previously, we reported that TLR4 activation is
reciprocally modulated by saturated and polyunsaturated fatty acids in macrophages.
However, it is not known whether fatty acids can modulate the activation of TLR2 or other
TLRs for which respective ligands do not require acylated fatty acids. A saturated fatty acid,
lauric acid, induced NFκB activation when TLR2 was co-transfected with TLR1 or TLR6 in …
saturated fatty acids in their molecules. Previously, we reported that TLR4 activation is
reciprocally modulated by saturated and polyunsaturated fatty acids in macrophages.
However, it is not known whether fatty acids can modulate the activation of TLR2 or other
TLRs for which respective ligands do not require acylated fatty acids. A saturated fatty acid,
lauric acid, induced NFκB activation when TLR2 was co-transfected with TLR1 or TLR6 in …