The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro
JS Beech, DW Wheeler, J Reckless, AJ Grant… - Journal of …, 2007 - Elsevier
Chemokines help to establish cerebral inflammation after ischemia, which comprises a
major component of secondary brain injury. The CXCR4 chemokine receptor system
induces neural stem cell migration, and hence has been implicated in brain repair. We show
that CXCR1 and interleukin-8 also stimulate chemotaxis in murine neural stem cells from the
MHP36 cell line. The presence of CXCR1 was confirmed by reverse transcriptase PCR and
immunohistochemistry. Interleukin-8 evoked intracellular calcium currents, upregulated …
major component of secondary brain injury. The CXCR4 chemokine receptor system
induces neural stem cell migration, and hence has been implicated in brain repair. We show
that CXCR1 and interleukin-8 also stimulate chemotaxis in murine neural stem cells from the
MHP36 cell line. The presence of CXCR1 was confirmed by reverse transcriptase PCR and
immunohistochemistry. Interleukin-8 evoked intracellular calcium currents, upregulated …