[HTML][HTML] Regulation of in situ to invasive breast carcinoma transition

M Hu, J Yao, DK Carroll, S Weremowicz, H Chen… - Cancer cell, 2008 - cell.com
M Hu, J Yao, DK Carroll, S Weremowicz, H Chen, D Carrasco, A Richardson, S Violette…
Cancer cell, 2008cell.com
The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly
understood key event in breast tumor progression. Here, we analyzed the role of
myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of
human DCIS and primary breast tumors. Progression to invasion was promoted by
fibroblasts and inhibited by normal myoepithelial cells. Molecular profiles of isolated luminal
epithelial and myoepithelial cells identified an intricate interaction network involving TGFβ …
Summary
The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors. Progression to invasion was promoted by fibroblasts and inhibited by normal myoepithelial cells. Molecular profiles of isolated luminal epithelial and myoepithelial cells identified an intricate interaction network involving TGFβ, Hedgehog, cell adhesion, and p63 required for myoepithelial cell differentiation, the elimination of which resulted in loss of myoepithelial cells and progression to invasion.
cell.com