Comparative genomic hybridization reveals complex genetic changes in primary breast cancer tumors and their cell lines
ML Larramendy, T Lushnikova, AM Björkqvist… - Cancer genetics and …, 2000 - Elsevier
DNA copy number changes were characterized by comparative genomic hybridization
(CGH) in 18 breast cancer cell lines. In 5 of these, the results were comparable with those
from the primary tumors of which the cell lines were established. All of the cell lines showed
extensive DNA copy number changes, with a mean of 16.3±1.1 aberrations per sample
(range 7–26). All of the cell lines had a gain at 8q22–qter. Other common gains of DNA
sequences occurred at 1q31–32 (89%), 20q12–q13. 2 (83%), 8q13 (72%), 3q26. 1–qter …
(CGH) in 18 breast cancer cell lines. In 5 of these, the results were comparable with those
from the primary tumors of which the cell lines were established. All of the cell lines showed
extensive DNA copy number changes, with a mean of 16.3±1.1 aberrations per sample
(range 7–26). All of the cell lines had a gain at 8q22–qter. Other common gains of DNA
sequences occurred at 1q31–32 (89%), 20q12–q13. 2 (83%), 8q13 (72%), 3q26. 1–qter …