[HTML][HTML] BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs
W Fan, S Jin, T Tong, H Zhao, F Fan… - Journal of biological …, 2002 - ASBMB
BRCA1, a breast and ovarian cancer susceptibility gene, has been implicated in gene
regulation. Previous studies demonstrate that BRCA1 induces GADD45, a p53-regulated
and stress-inducible gene that plays an important role in cellular response to DNA damage.
However, the mechanism (s) by which BRCA1 regulates GADD45 remains unclear. In this
report, we have shown that BRCA1 activation of the GADD45 promoter is mediated through
the OCT-1 and CAAT motifs located at theGADD45 promoter region. Site-directed mutations …
regulation. Previous studies demonstrate that BRCA1 induces GADD45, a p53-regulated
and stress-inducible gene that plays an important role in cellular response to DNA damage.
However, the mechanism (s) by which BRCA1 regulates GADD45 remains unclear. In this
report, we have shown that BRCA1 activation of the GADD45 promoter is mediated through
the OCT-1 and CAAT motifs located at theGADD45 promoter region. Site-directed mutations …