[HTML][HTML] p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle
M Ciciarello, R Mangiacasale, M Casenghi… - Journal of Biological …, 2001 - ASBMB
Growing evidence indicates a central role for p53 in mediating cell cycle arrest in response
to mitotic spindle defects so as to prevent rereplication in cells in which the mitotic division
has failed. Here we report that a transient inhibition of spindle assembly induced by
nocodazole, a tubulin-depolymerizing drug, triggers a stable activation of p53, which can
transduce a cell cycle inhibitory signal even when the spindle-damaging agent is removed
and the spindle is allowed to reassemble. Cells transiently exposed to nocodazole continue …
to mitotic spindle defects so as to prevent rereplication in cells in which the mitotic division
has failed. Here we report that a transient inhibition of spindle assembly induced by
nocodazole, a tubulin-depolymerizing drug, triggers a stable activation of p53, which can
transduce a cell cycle inhibitory signal even when the spindle-damaging agent is removed
and the spindle is allowed to reassemble. Cells transiently exposed to nocodazole continue …