Isoflurane-induced dilation of porcine coronary arterioles is mediated by ATP-sensitive potassium channels

X Zhou, W Abboud, NC Manabat… - The Journal of the …, 1998 - pubs.asahq.org
Background Isoflurane causes increases in coronary blood flow in vivo, which are mediated
by the adenosine triphosphate (ATP)-sensitive potassium channels, but the role of the
arterioles (resistance vessels) in these responses is controversial. Methods Medium porcine
coronary arterioles (internal diameter, 172+/-51 [SD] microm) were placed in a chamber
supplied with Kreb's buffer, pressurized (40 mmHg), and preconstricted with acetylcholine
(10 (-8)-10 (-6) M). Vascular diameter (VD) was assessed using an optical density video …