Doppler estimation of reduced coronary flow reserve in mice with pressure overload cardiac hypertrophy
CJ Hartley, AK Reddy, S Madala, LH Michael… - Ultrasound in medicine …, 2008 - Elsevier
Aortic banding produces pressure overload cardiac hypertrophy in mice, leading to
decompensated heart failure in four to eight weeks, but the effects on coronary blood flow
velocity and reserve are unknown. To determine whether coronary flow reserve (CFR) was
reduced, we used noninvasive 20-MHz Doppler ultrasound to measure left main coronary
flow velocity at baseline (B) and at hyperemia (H) induced by low (1%) and high (2.5%)
concentrations of isoflurane gas anesthesia. Ten mice were studied before (Pre) and at 1 d …
decompensated heart failure in four to eight weeks, but the effects on coronary blood flow
velocity and reserve are unknown. To determine whether coronary flow reserve (CFR) was
reduced, we used noninvasive 20-MHz Doppler ultrasound to measure left main coronary
flow velocity at baseline (B) and at hyperemia (H) induced by low (1%) and high (2.5%)
concentrations of isoflurane gas anesthesia. Ten mice were studied before (Pre) and at 1 d …