The p38-MAPK pathway plays an important role in myocardial ischaemia/reperfusion injury
and has been implicated in the regulation of cardiac gene expression, myocyte hypertrophy,
inflammation, energetic metabolism, contractility, proliferation and apoptosis. The activation
of p38-MAPK by dual phosphorylation during myocardial ischaemia aggravates lethal injury.
However, under other circumstances activation can protect the heart, and recent evidence
suggests that the mechanism of p38-MAPK activation may differ by circumstance …