Mechanical stretching of human saphenous vein grafts induces expression and activation of matrix-degrading enzymes associated with vascular tissue injury and …
X Meng, K Mavromatis, ZS Galis - Experimental and molecular pathology, 1999 - Elsevier
After coronary artery bypass surgery, saphenous vein graft occlusion occurs through tissue
remodeling. Although a likely trigger, the role of preparative mechanical injury incurred by
the graft is not yet understood. We studied the early effects of simple mechanical injury on
human saphenous vein grafts by exposing them to longitudinal stretch, a deformation which
potentially occurs during surgery. We then maintained ex vivo for up to 7 days matched pairs
of experimentally stretched and nonstretched (control) vein segments and examined the …
remodeling. Although a likely trigger, the role of preparative mechanical injury incurred by
the graft is not yet understood. We studied the early effects of simple mechanical injury on
human saphenous vein grafts by exposing them to longitudinal stretch, a deformation which
potentially occurs during surgery. We then maintained ex vivo for up to 7 days matched pairs
of experimentally stretched and nonstretched (control) vein segments and examined the …