Ultrasound imaging of renal vaso-occlusive events in transgenic sickle mice exposed to hypoxic stress
P Bonnin, N Sabaa, M Flamant, H Debbabi… - Ultrasound in medicine …, 2008 - Elsevier
One of the major clinical manifestations of sickle cell disease (SCD) is vaso-occlusive crisis
in response to hypoxic exposure, leading to acute and chronic organ damages, especially in
kidneys. In a SCD transgenic murine model, ultrasound imaging allowed us to characterize
the circulatory changes in renal arteries during vaso-occlusive crisis. Cardiac output, heart
rate and renal blood flow velocities (BFV) were measured in 10 male transgenic and 10
male wild-type (WT) mice with a conventional echograph (Vivid 7, GE Medical), before and …
in response to hypoxic exposure, leading to acute and chronic organ damages, especially in
kidneys. In a SCD transgenic murine model, ultrasound imaging allowed us to characterize
the circulatory changes in renal arteries during vaso-occlusive crisis. Cardiac output, heart
rate and renal blood flow velocities (BFV) were measured in 10 male transgenic and 10
male wild-type (WT) mice with a conventional echograph (Vivid 7, GE Medical), before and …