[HTML][HTML] DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation
S Milutinovic, SE Brown, Q Zhuang, M Szyf - Journal of Biological Chemistry, 2004 - ASBMB
DNA methyltransferase 1 (DNMT1) catalyzes the post-replication methylation of DNA and is
responsible for maintaining the DNA methylation pattern during cell division. A long list of
data supports a role for DNMT1 in cellular transformation and inhibitors of DNMT1 were
shown to have antitumorigenic effects. It was long believed that DNMT1 promoted
tumorigenesis by maintaining the hypermethylated and silenced state of tumor suppressor
genes. We have previously shown that DNMT1 knock down by either antisense …
responsible for maintaining the DNA methylation pattern during cell division. A long list of
data supports a role for DNMT1 in cellular transformation and inhibitors of DNMT1 were
shown to have antitumorigenic effects. It was long believed that DNMT1 promoted
tumorigenesis by maintaining the hypermethylated and silenced state of tumor suppressor
genes. We have previously shown that DNMT1 knock down by either antisense …