[HTML][HTML] Nuclear survivin as a biomarker for non-small-cell lung cancer
British journal of cancer, 2004•nature.com
Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or
cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-
cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse
survival (relative risk: 3.9, P= 0.02). Therefore, survivin may be a biomarker for NSCLC.
cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-
cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse
survival (relative risk: 3.9, P= 0.02). Therefore, survivin may be a biomarker for NSCLC.
Abstract
Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P= 0.02). Therefore, survivin may be a biomarker for NSCLC.
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