Breast cancer susceptibility gene BRCA1 is implicated in the control of mitotic progression,
although the underlying mechanism (s) remains to be further defined. Deficiency of BRCA1
function leads to disrupted mitotic machinery and genomic instability. Here, we show that
BRCA1 physically interacts and colocalizes with Nlp, an important molecule involved in
centrosome maturation and spindle formation. Interestingly, Nlp centrosomal localization
and its protein stability are regulated by normal cellular BRCA1 function because cells …