[HTML][HTML] Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice
This study was undertaken to elucidate the mechanism underling the protective effect of a
high saturated fat (HSF) diet against the development of alcoholic fatty liver in mice. We
tested the effects of a HSF diet on the ethanol-mediated increase in hepatic sterol regulatory
element binding protein 1 (SREBP-1) activity. Thirty-two male mice were divided into 4
groups and fed liquid diets consisting of either a high polyunsaturated fat (40% of energy
from corn oil) or a HSF (40% of energy from cocoa butter) diet with or without ethanol for 4 …
high saturated fat (HSF) diet against the development of alcoholic fatty liver in mice. We
tested the effects of a HSF diet on the ethanol-mediated increase in hepatic sterol regulatory
element binding protein 1 (SREBP-1) activity. Thirty-two male mice were divided into 4
groups and fed liquid diets consisting of either a high polyunsaturated fat (40% of energy
from corn oil) or a HSF (40% of energy from cocoa butter) diet with or without ethanol for 4 …