The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
AL Hodgkin, AF Huxley - The Journal of physiology, 1952 - ncbi.nlm.nih.gov
AL Hodgkin, AF Huxley
The Journal of physiology, 1952•ncbi.nlm.nih.govRESULTS The influence of a small change in membrane potential on the ability of the
membrane to undergo its increase in sodium permeability is illustrated by Fig. 1. In this
experiment the membrane potential was changed in two steps. The amplitude of the first
stepwas-8 mV. and its duration varied between O and 50 msec. This step will be called the
conditioning voltage (V1). It was followed by a second step called the test voltage (V2) which
was kept at a con-stant amplitude of-44 mV. Record A gives the current observed with the …
membrane to undergo its increase in sodium permeability is illustrated by Fig. 1. In this
experiment the membrane potential was changed in two steps. The amplitude of the first
stepwas-8 mV. and its duration varied between O and 50 msec. This step will be called the
conditioning voltage (V1). It was followed by a second step called the test voltage (V2) which
was kept at a con-stant amplitude of-44 mV. Record A gives the current observed with the …
RESULTS
The influence of a small change in membrane potential on the ability of the membrane to undergo its increase in sodium permeability is illustrated by Fig. 1. In this experiment the membrane potential was changed in two steps. The amplitude of the first stepwas-8 mV. and its duration varied between O and 50 msec. This step will be called the conditioning voltage (V1). It was followed by a second step called the test voltage (V2) which was kept at a con-stant amplitude of-44 mV.
Record A gives the current observed with the test voltage alone. BF show the effect of preceding this by a conditioning pulse of varying duration. Although the depolarization of8 mV. was not associated with any appreciable inward current it greatly altered the subsequent response of the nerve. Thus, if theconditioning voltage lasted longer than 20 msec., it reduced the inward
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