Short hairpin RNA–mediated selective knockdown of NaV1. 8 tetrodotoxin-resistant voltage-gated sodium channel in dorsal root ganglion neurons
M Mikami, J Yang - The Journal of the American Society of …, 2005 - pubs.asahq.org
Background Voltage-gated sodium channels comprise a family of closely related proteins,
each subserving different physiologic and pathologic functions. NaV1. 8 is an isoform of
voltage-gated sodium channel implicated in the pathogenesis of inflammatory and
neuropathic pain, but currently, there is no isoform-specific inhibitor of any voltage-gated
sodium channels. The authors explored the possibility of short hairpin RNA-mediated
selective knockdown of NaV1. 8 expression. Methods DNA constructs designed to transcribe …
each subserving different physiologic and pathologic functions. NaV1. 8 is an isoform of
voltage-gated sodium channel implicated in the pathogenesis of inflammatory and
neuropathic pain, but currently, there is no isoform-specific inhibitor of any voltage-gated
sodium channels. The authors explored the possibility of short hairpin RNA-mediated
selective knockdown of NaV1. 8 expression. Methods DNA constructs designed to transcribe …