[HTML][HTML] Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons
J Fjell, TR Cummins, SD Dib-Hajj, K Fried… - Molecular brain …, 1999 - Elsevier
Following sciatic nerve transection, the electrophysiological properties of small dorsal root
ganglion (DRG) neurons are markedly altered, with attenuation of TTX-R sodium currents
and the appearance of rapidly repriming TTX-S currents. The reduction in TTX-R currents
has been attributed to a down-regulation of sodium channels SNS/PN3 and NaN. While
infusion of exogenous NGF to the transected nerve restores SNS/PN3 transcripts to near-
normal levels in small DRG neurons, TTX-R sodium currents are only partially rescued …
ganglion (DRG) neurons are markedly altered, with attenuation of TTX-R sodium currents
and the appearance of rapidly repriming TTX-S currents. The reduction in TTX-R currents
has been attributed to a down-regulation of sodium channels SNS/PN3 and NaN. While
infusion of exogenous NGF to the transected nerve restores SNS/PN3 transcripts to near-
normal levels in small DRG neurons, TTX-R sodium currents are only partially rescued …