Kruppel-like Factors (KLFs) in muscle biology

SM Haldar, OA Ibrahim, MK Jain - Journal of molecular and cellular …, 2007 - Elsevier
SM Haldar, OA Ibrahim, MK Jain
Journal of molecular and cellular cardiology, 2007Elsevier
The Kruppel-like Factor (KLF) family of zinc-finger transcription factors are critical regulators
of cell differentiation, phenotypic modulation and physiologic function. An emerging body of
evidence implicates an important role for these factors in cardiovascular biology, however,
the role of KLFs in muscle biology is only beginning to be understood. This article reviews
the published data describing the role of KLFs in the heart, smooth muscle, and skeletal
muscle and highlights the importance of these factors in cardiovascular development …
The Kruppel-like Factor (KLF) family of zinc-finger transcription factors are critical regulators of cell differentiation, phenotypic modulation and physiologic function. An emerging body of evidence implicates an important role for these factors in cardiovascular biology, however, the role of KLFs in muscle biology is only beginning to be understood. This article reviews the published data describing the role of KLFs in the heart, smooth muscle, and skeletal muscle and highlights the importance of these factors in cardiovascular development, physiology and disease pathobiology.
Elsevier