[HTML][HTML] FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
G Yang, CY Lim, C Li, X Xiao, GK Radda, C Li… - Journal of biological …, 2009 - ASBMB
Leptin controls food intake and energy expenditure by regulating hypothalamic neuron
activities. Leptin exerts its actions through complex signaling pathways including STAT3
phosphorylation, nuclear translocation, and binding to target gene promoter/cofactor
complexes. Deficient or defective leptin signaling leads to obesity, which may be caused by
insufficient leptin levels and/or resistance to leptin signaling. To understand the molecular
mechanisms of leptin resistance, we studied the regulation of pro-opiomelanocortin (POMC) …
activities. Leptin exerts its actions through complex signaling pathways including STAT3
phosphorylation, nuclear translocation, and binding to target gene promoter/cofactor
complexes. Deficient or defective leptin signaling leads to obesity, which may be caused by
insufficient leptin levels and/or resistance to leptin signaling. To understand the molecular
mechanisms of leptin resistance, we studied the regulation of pro-opiomelanocortin (POMC) …