[HTML][HTML] Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula …
PL Sorgen, HS Duffy, P Sahoo, W Coombs… - Journal of Biological …, 2004 - ASBMB
Regulation of cell-cell communication by the gap junction protein connexin43 can be
modulated by a variety of connexin-associating proteins. In particular, c-Src can disrupt the
connexin43 (Cx43)-zonula occludens-1 (ZO-1) interaction, leading to down-regulation of
gap junction intercellular communication. The binding sites for ZO-1 and c-Src correspond to
widely separated Cx43 domains (∼ 100 residues apart); however, little is known about the
structural modifications that may allow information to be transferred over this distance. Here …
modulated by a variety of connexin-associating proteins. In particular, c-Src can disrupt the
connexin43 (Cx43)-zonula occludens-1 (ZO-1) interaction, leading to down-regulation of
gap junction intercellular communication. The binding sites for ZO-1 and c-Src correspond to
widely separated Cx43 domains (∼ 100 residues apart); however, little is known about the
structural modifications that may allow information to be transferred over this distance. Here …