Thymic microenvironments, 3-D versus 2-D?
W Van Ewijk, BP Wang, G Hollander, H Kawamoto… - Seminars in …, 1999 - Elsevier
W Van Ewijk, BP Wang, G Hollander, H Kawamoto, E Spanopoulou, M Itoi, T Amagai…
Seminars in immunology, 1999•ElsevierLympho-stromal interactions in the thymus crucially de-termine the fate of developing T cells.
Epithelial cells, inter-digitating reticular cells, macrophages and fibroblasts all play a role in
the shaping of the T cell repertoire. Recently published evidence shows that lympho-stromal
interaction acts bi-directional. Developing T cell themselves, at different stages of
differentiation, control the microarchitecture of thymic microenvironments, a phenomenon
designated ascrosstalk'. This paper reviews experiments showing that developing T cells …
Epithelial cells, inter-digitating reticular cells, macrophages and fibroblasts all play a role in
the shaping of the T cell repertoire. Recently published evidence shows that lympho-stromal
interaction acts bi-directional. Developing T cell themselves, at different stages of
differentiation, control the microarchitecture of thymic microenvironments, a phenomenon
designated ascrosstalk'. This paper reviews experiments showing that developing T cells …
Lympho-stromal interactions in the thymus crucially de- termine the fate of developing T cells. Epithelial cells, inter- digitating reticular cells, macrophages and fibroblasts all play a role in the shaping of the T cell repertoire. Recently published evidence shows that lympho-stromal interaction acts bi-directional. Developing T cell themselves, at different stages of differentiation, control the microarchitecture of thymic microenvironments, a phenomenon designated as `crosstalk'. This paper reviews experiments showing that developing T cells crosstalk to different thymic epithelial cells in a stepwise fashion. In this way, correctly organized thymic microenvironments guarantee normal thymopoiesis.
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