[HTML][HTML] Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects
The small heat shock protein Hsp20 protects cardiomyocytes against apoptosis, and
phosphorylation at its Ser 16 site enhances its cardioprotection. To determine whether
genetic variants exist in human Hsp20, which may modify these beneficial effects, we
sequenced the coding region of the Hsp20 gene in 1347 patients suffering from dilated
cardiomyopathy and 744 subjects with no heart disease. We identified a C59T substitution in
the human Hsp20 gene in one patient and three individuals without heart disease. All …
phosphorylation at its Ser 16 site enhances its cardioprotection. To determine whether
genetic variants exist in human Hsp20, which may modify these beneficial effects, we
sequenced the coding region of the Hsp20 gene in 1347 patients suffering from dilated
cardiomyopathy and 744 subjects with no heart disease. We identified a C59T substitution in
the human Hsp20 gene in one patient and three individuals without heart disease. All …