β2-adrenergic receptor genotype and survival among patients receiving β-blocker therapy after an acute coronary syndrome
DE Lanfear, PG Jones, S Marsh, S Cresci, HL McLeod… - Jama, 2005 - jamanetwork.com
ContextPrevious data support an association between polymorphisms of the β1-and β2-
adrenergic receptors (ADRB1 and ADRB2) and surrogate end points of response to β-
adrenergic blocker therapy. However, no associations between these polymorphisms and
mortality have been demonstrated. ObjectiveTo evaluate the effect of ADRB1 Arg389Gly
(1165 CG), Ser49Gly (145 AG), and ADRB2 Gly16Arg (46 GA), Gln27Glu (79 CG) genotypes
on survival among patients discharged with prescribed β-blockers after an acute coronary …
adrenergic receptors (ADRB1 and ADRB2) and surrogate end points of response to β-
adrenergic blocker therapy. However, no associations between these polymorphisms and
mortality have been demonstrated. ObjectiveTo evaluate the effect of ADRB1 Arg389Gly
(1165 CG), Ser49Gly (145 AG), and ADRB2 Gly16Arg (46 GA), Gln27Glu (79 CG) genotypes
on survival among patients discharged with prescribed β-blockers after an acute coronary …