[HTML][HTML] Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria …
J Jin, Q Hou, TD Mullen, YH Zeidan, J Bielawski… - Journal of biological …, 2008 - ASBMB
Ceramide functions as an important second messenger in apoptosis signaling pathways. In
this report, we show that treatment of NT-2 neuronal precursor cells with
hypoxia/reoxygenation (H/R) resulted in ceramide up-regulation. This elevation in ceramide
was primarily due to the actions of acid sphingomyelinase and ceramide synthase LASS 5,
demonstrating the action of the salvage pathway. Hypoxia/reoxygenation treatment led to
Bax translocation from the cytoplasm to mitochondria and cytochrome c release from …
this report, we show that treatment of NT-2 neuronal precursor cells with
hypoxia/reoxygenation (H/R) resulted in ceramide up-regulation. This elevation in ceramide
was primarily due to the actions of acid sphingomyelinase and ceramide synthase LASS 5,
demonstrating the action of the salvage pathway. Hypoxia/reoxygenation treatment led to
Bax translocation from the cytoplasm to mitochondria and cytochrome c release from …