The role of focal-adhesion kinase in cancer—a new therapeutic opportunity
GW McLean, NO Carragher, E Avizienyte… - Nature Reviews …, 2005 - nature.com
GW McLean, NO Carragher, E Avizienyte, J Evans, VG Brunton, MC Frame
Nature Reviews Cancer, 2005•nature.comFocal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell
proliferation, cell survival and cell migration. Given that the development of malignancy is
often associated with perturbations in these processes, it is not surprising that FAK activity is
altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation
and progression, and other studies showing that FAK expression is increased in human
tumours make FAK a potentially important new therapeutic target.
proliferation, cell survival and cell migration. Given that the development of malignancy is
often associated with perturbations in these processes, it is not surprising that FAK activity is
altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation
and progression, and other studies showing that FAK expression is increased in human
tumours make FAK a potentially important new therapeutic target.
Abstract
Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.
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