[HTML][HTML] Comparison of serous and mucinous ovarian carcinomas: distinct pattern of allelic loss at distal 8p and expression of transcription factor GATA-4

H Lassus, MPE Laitinen, M Anttonen… - Laboratory …, 2001 - Elsevier
Using comparative genomic hybridization (CGH), we have previously demonstrated frequent
loss of 8p, especially its distal part, in ovarian carcinoma. To compare the deletion map of
distal 8p in serous and mucinous ovarian carcinomas, we performed allelic analysis with 18
polymorphic microsatellite markers at 8p21–p23. In serous carcinoma, loss of heterozygosity
(LOH) was detected in 67% of the samples, and the majority of the carcinomas showed loss
of all or most of the informative markers. In contrast, only 21% of mucinous carcinomas …